Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats.

Tugba E. K., Medine G. I. O., Ozlem A., Deniz K., ONAT F.

Pharmacology, biochemistry, and behavior, vol.213, pp.173317, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 213
  • Publication Date: 2022
  • Doi Number: 10.1016/j.pbb.2021.173317
  • Journal Name: Pharmacology, biochemistry, and behavior
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.173317
  • Keywords: Epilepsy, 6-OHDA, GAERS, Wistar, Medial forebrain bundle, Basal ganglia, NIGRA PARS RETICULATA, BASAL GANGLIA, NETWORK MECHANISMS, WAVE DISCHARGES, MODEL, SPIKE, ADULT, NEURONS, 6-HYDROXYDOPAMINE, LESIONS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objective: Basal ganglia structures play an important role in the pathophysiology of absence epilepsy, known as remote control of absence seizures. We examined the role of the nigrostriatal dopaminergic pathway in absence epilepsy through behavioral and electroencephalography (EEG) parameters, immunohistochemical, and biochemical characteristics of dopamine and serotonin in the genetic absence epilepsy rat model.