Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor

Ersoy Ö.

WORLD JOURNAL OF GASTROENTEROLOGY, vol.11, no.44, pp.7051-7053, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 44
  • Publication Date: 2005
  • Doi Number: 10.3748/wjg.v11.i44.7051
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.7051-7053
  • Keywords: Hepatocellular carcinoma, Sertoli-Leydig cell tumor, AFP, Cirrhosis, Hypercholesterolemia
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor([7]). HCC is one of the most common malignancies worldwide and the incidence of HCC increases with age([8]). The relationship between hepatitis B incidence and HCC rates is also well recognized. Alpha fetoprotein (AFP) is produced by 70% of HCC. Though a level of AFP >400 ng/mL is diagnostic for HCC, in the presence of active hepatitis B infection, the cut-off level should be considered to be at least 1 000-4 000 ng/mL. Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP([10]). Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.