Mechanisms of reproductive dysfunction in classical and nonclassical congenital Adrenal Hyperplasia: From an endocrinologist's perspective
Fertility and Reproductive Outcomes in Different Forms of Congenital Adrenal Hyperplasia, Springer International Publishing Ag, ss.63-91, 2021
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2021
- Doi Numarası: 10.1007/978-3-030-82591-1_5
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.63-91
- Anahtar Kelimeler: Adrenal Hyperplasia, Congenital, Adrenal rest tumor, Fertility, Pregnancy, Reproduction
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders arising from defective steroidogenesis caused by mutations of genes which encode enzymes of cortisol biosynthesis. Despite optimal glucocorticoid replacement therapy, patients have to struggle with a variety of problems; impaired fertility is one of them. The reasons for infertility include anovulation, progesterone hypersecretion, testicular adrenal rest tumors, virilization of external genitalia, impaired psychosocial development, negative effects of unsuccessful genital surgery, and reduced heterosexual partnership.