The Effect of Quetiapine on Treatment of Experimental Acute Spinal Cord Injury


AYTAR M. H. , Civi S., Kaymaz M., Ergun E., KAYMAZ F. F. , Pasaoglu A.

TURKISH NEUROSURGERY, vol.28, no.1, pp.105-110, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5137/1019-5149.jtn.17476-16.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.105-110
  • Keywords: Spinal cord injury, Quetiapine, Apoptosis, Secondary damage, EARLY ULTRASTRUCTURAL FINDINGS, LIPID-PEROXIDATION, CELL-DEATH, APOPTOSIS, RATS, SARPOGRELATE, ERYTHROPOIETIN, ANTAGONIST, MODELS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

AIM: It is well known that treatment modalities against secondary damage due to spinal cord injury (SCI) are very important. This phase has been researched in many experimental studies. Apoptosis is one of the major mechanisms of secondary damage on spinal cord. The present study was undertaken to determine if quetiapine, a 5-HT2 receptor blocker atypical antipsychotic agent can rescue neuronal cells from apoptosis in a SCI model.