Effect of prenatal glucocorticoids and postnatal nitric oxide inhalation on survival of newborn rats with nitrofen-induced congenital diaphragmatic hernia


Mann O., Huppertz C., Langwieler T., Tander B. , Bloechle C., Izbicki J., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.37, no.5, pp.730-734, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 5
  • Publication Date: 2002
  • Doi Number: 10.1053/jpsu.2002.32265
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.730-734

Abstract

Background/Purpose: Pulmonary hypertension and pulmonary hypoplasia account for the high mortality rate associated with congenital diaphragmatic hernia (CDH). In animal models of CDH, postnatal nitric oxide (NO) inhalation resulted in significantly better survival rates and antenatal glucocorticoid administration in improved lung compliance. The objective of this study was to evaluate the combined effect of prenatal glucocorticoid administration and postnatal NO inhalation on the survival rate of newborn rats with nitrofen-induced CDH.