Akademik Veri Yönetim Sistemi
FABAD JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.48, sa.2, ss.303-318, 2023 (Scopus)
Thirdhand smoke (THS) is a newly described environmental health
hazard that might be defined as residual cigarette smoke that occurs
due to the accumulation of toxins of second-hand smoke (SHS) in
the smoking environment. In addition, the chemicodynamic of THS
may alter due to the interaction with other gases and chemicals in the
environment. THS may cause serious health outcomes in the lungs,
liver, skin, heart, and nervous system as well. Hence, it is thought to
represent a major health hazard for people, particularly children, who
are exposed to THS, where they interact more frequently with these
surfaces exposed to THS via hand-to-mouth transfer. In the present
study, it was aimed to summarize the proposed toxicity mechanisms
based on in vitro and in vivo studies based on target organ toxicity. In
this study, it is aimed to review the toxicity mechanisms of THS based
on in vitro and in vivo studies on target organ toxicity. Recent studies
reported that THS might induce unwanted effects in the respiratory,
cardiovascular, nervous, hematopoietic, and skeletal systems and skin.
Literature data indicated that THS-mediated oxidative damage and
an increase in inflammatory response may play an important role
in the pathogenesis of cardiovascular and neurobehavioral diseases,
especially the target organ lung. In the future, THS might be defined
as a preventable environmental risk factor. Therefore, further studies
on THS are needed to define its toxicity mechanism as well as increase
social awareness and legal regulations.