Assessment of the relevance of GaPc substituted with azido-polyethylene glycol chains for photodynamic therapy. Design, synthetic strategy, fluorescence, singlet oxygen generation, and pH-dependent spectroscopic behaviour


Koc V., Topal S. Z. , Tekdas D. A. , Ates O. D. , Onal E., DUMOULIN F. , ...Daha Fazla

NEW JOURNAL OF CHEMISTRY, cilt.41, ss.10027-10036, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41 Konu: 18
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1039/c7nj01390f
  • Dergi Adı: NEW JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.10027-10036

Özet

A new efficient synthetic route was used to obtain symmetrically and asymmetrically substituted gallium(III) phthalocyanines (5-GaCl and 6-GaCl) containing azido groups with chlorine atoms at axial positions, using corresponding ZnPc derivatives (5-Zn and 6-Zn) as precursors. The photophysical and photochemical properties-fluorescence, singlet oxygen generation, and photodegradation-of 5-GaCl and 6-GaCl were compared with that of 5-Zn and 6-Zn. Their pH-sensitive spectral changes were also investigated in detail, as tumours are more acidic than healthy tissues. Their amphiphilicity, quantified by their partition coefficient, appeared suitable for biological applications. 5-GaCl and 6-GaCl exhibited higher photodynamic potential than unsubstituted gallium(III) phthalocyanine, suggesting potential to be used as a photodynamic therapy agent.