Assessment of the relevance of GaPc substituted with azido-polyethylene glycol chains for photodynamic therapy. Design, synthetic strategy, fluorescence, singlet oxygen generation, and pH-dependent spectroscopic behaviour

Koc V., Topal S. Z., Tekdas D. A., Ates O. D., Onal E., DUMOULIN F., ...Daha Fazla

NEW JOURNAL OF CHEMISTRY, cilt.41, sa.18, ss.10027-10036, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 18
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1039/c7nj01390f
  • Dergi Adı: NEW JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10027-10036
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

A new efficient synthetic route was used to obtain symmetrically and asymmetrically substituted gallium(III) phthalocyanines (5-GaCl and 6-GaCl) containing azido groups with chlorine atoms at axial positions, using corresponding ZnPc derivatives (5-Zn and 6-Zn) as precursors. The photophysical and photochemical properties-fluorescence, singlet oxygen generation, and photodegradation-of 5-GaCl and 6-GaCl were compared with that of 5-Zn and 6-Zn. Their pH-sensitive spectral changes were also investigated in detail, as tumours are more acidic than healthy tissues. Their amphiphilicity, quantified by their partition coefficient, appeared suitable for biological applications. 5-GaCl and 6-GaCl exhibited higher photodynamic potential than unsubstituted gallium(III) phthalocyanine, suggesting potential to be used as a photodynamic therapy agent.