A checklist for critical appraisal of studies of biological variation

Bartlett W. A. , Braga F., Carobene A., COŞKUN A. , Prusa R., Fernandez-Calle P., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.53, no.6, pp.879-885, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1515/cclm-2014-1127
  • Page Numbers: pp.879-885
  • Keywords: biological variation, checklist, critical appraisal, reference values, APPROVED RECOMMENDATION 1987, REFERENCE VALUES, NEED


Data on biological variation are used for many purposes in laboratory medicine but concern exists over the validity of the data reported in some studies. A critical appraisal checklist has been produced by a working group established by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) to enable standardised assessment of existing and future publications of biological variation data. The checklist identifies key elements to be reported in studies to enable safe accurate and effective transport of biological variation data sets across healthcare systems. The checklist is mapped to the domains of a minimum data set required to enable this process.