Effects of betulinic acid on AKT/mTOR pathway in renal cell carcinoma

Atas M. N., Ertuğrul B., Bireller E. S., Çakmakoğlu B., Ergen A.

TURKISH JOURNAL OF UROLOGY, cilt.48, sa.1, ss.58-63, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/tud.2022.21276
  • Dergi Adı: TURKISH JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.58-63
  • Anahtar Kelimeler: Apoptosis, betulinic acid, expression, pathway, renal cancer, TRITERPENOIDS, CANCER, ACTIVATION, APOPTOSIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Renal cancer is the most lethal among urological cancer. Treatments of renal cell carcinoma (RCC) may be possible by immune checkpoint inhibitors and drug treatment targeting different molecules. We aimed to determine the apoptotic effect of betulinic acid and its effects on expressions of apoptosis-associated genes AKT-1 and mTOR in RCC cells.