Association Among SNAP-25 Gene DdeI and MnlI Polymorphisms and Hemodynamic Changes During Methylphenidate Use: A Functional Near-Infrared Spectroscopy Study


Oner O., Akin A., Herken H., Erdal M. E. , Ciftci K., Ay M. E. , ...More

JOURNAL OF ATTENTION DISORDERS, vol.15, no.8, pp.628-637, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1177/1087054710374597
  • Journal Name: JOURNAL OF ATTENTION DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.628-637
  • Keywords: functional near-infrared spectroscopy, ADHD, methylphenidate, SNAP-25, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DOPAMINE TRANSPORTER GENOTYPE, UTAH RATING-SCALE, CEREBRAL HEMODYNAMICS, CHILDREN, TASK, HYPERKINESIA, RELIABILITY, ACTIVATION, VALIDITY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objective: To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method: A total of 15 right-handed adults and 16 right-handed children with DSM-IV diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results: Participants with SNAP-25 DdeI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 MnlI genotype was also associated with right deoxyhemoglobin ([HbO(2)]) and [HHb] changes as well as left [HHb] change. When the combinations of these genotypes were taken into account, the participants with [DdeI C/C or T/C and MnlI G/G or T/G] genotype had increased right [HHb] with MPH use whereas the participants with [DdeI T/T and MnlI T/T] or [DdeI T/T and MnlI G/G or T/G] genotypes had decreased right prefrontal [HHb]. Conclusions: These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants. (J. of Att. Dis. 2011; 15(8) 628-637)