Akademik Veri Yönetim Sistemi
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI, cilt.28, sa.8, ss.560-564, 2022 (SCI-Expanded)
y experimental study, BTx (15U/kg ) was administered directly and intraductal ways. After 10 days, blood amylase, lipase, trypsinogen, insulin and glucagon levels were compared and no significant difference was seen between groups. Intradcutal BTx administration is preferred for experimental AP modelin rats; Control, Acute Pancreatitis (AP), Intraductal Botulinum toxin (BTx) and Acute Pancreatitis with Intradcutal Botulinum toxin (AP+BTx). Acute pancreatitis was created by intraperitoneal injection of cerulean 20µg/kg/injection (five times). After 24 hours, Serum amilase, lipase, IL-6, IL-1β, TNF-α, and IL-10 were measured and pancreas tissue was evaluated for inflammation and necrosis.
Results: Mean serum amylase, lipase IL-6, IL-1β, and TNF-α levels of the AP group was significantly higher compared to the other groups (P<0.05). However, there was no significant difference between the amylase and lipase levels of control, BTx and AP+BTx groups. Serum insulin and glucagon levels in AP group were significantly higher than control and BTx groups (p<0.05). However there’s no significant difference between the insulin and glucagon levesl of AP and AP+BTx groups. In pathological evaluation ). In AP+ BTx group, there’s less amount of centrilobular necrosis and there’s mild inflamamtion and hyperplasia of pancreatic duct epithelium
Conclusions: Administration of intraductal BTx suppressed the AP without making significant suppression in endogenous activity of pancreas.