Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.11, sa.1, ss.25-29, 2000 (Scopus, TRDizin)
This study compares the efficacy of two triple combination regimens, including omeprazole or lansoprazole, for the treatment of Helicobacter pylori (H. Pylori) associated gastritis or duodenal ulcer. Forty-two patients with endoscopically proven gastritis and/or peptic ulcer were randomly divided into two groups. The first group (mean age: 46±12; 11 M, 10 F) received lansoprazole 30 mg. b.i.d. for one month, clarithromycin 250 mg. r.i.d. daily for 15 days and amoxycillin 1gr. b.i.d. for 15 days (LCA). The second group was given omeprazole 20 mg. b.i.d. for 1 month in addition to the same antibiotic combination as the first group (OCA). After this treatment, both groups received maintenance therapy of famotidine 40 mg daily for six weeks followed by endoscopic examination. Chi-square and Mann-Whitney U tests were used for statistical analysis. Helicobacter pylori eradication rates were 67% with LCA and 76% with OCA. Gastric activity decreased significantly with eradication in both groups, including OCA patients in whom H. pylori eradication was not achieved. There were no significant differences between the two combinations with respect to eradication, reduction in gastric activity or H. pylori intensity. All duodenal ulcers in both groups were observed to heal completely with treatment, regardless of H. pylori eradication in both groups. A considerable reduction in gastric activity and H. pylori intensity was noted in all patients with duodenal ulcers. In conclusion, both triple combinations were of similar efficacy in eradication of H. pylori associated peptic disorders. Neither combination yielded superior results as reported in previous studies. The long treatment period and high cost are major drawbacks for both combinations.