Comparing glutamatergic neuron population in the mediodorsal thalamic nucleus of genetic absence epilepsy rats from strasbourg (GAERS) and normal control Wistar rats

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Cavdar S., Ozgur M., KİRAZLI Ö., Karahuseyinoglu S., Onat F.

JOURNAL OF CHEMICAL NEUROANATOMY, vol.77, pp.93-99, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 77
• Publication Date: 2016
• Doi Number: 10.1016/j.jchemneu.2016.05.009
• Journal Name: JOURNAL OF CHEMICAL NEUROANATOMY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.93-99
• Keywords: Glutamate, Mediodorsal thalamic nucleus, Absence epilepsy, Quantification immunohistochemistry, GENERALIZED PENICILLIN EPILEPSY, MAL-LIKE SEIZURES, WAVE DISCHARGES, NONCONVULSIVE EPILEPSY, CORTEX, MODEL, SPIKE, MECHANISMS, SCHIZOPHRENIA, POSTMORTEM
• Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

An imbalance between GABAergic inhibition and glutamatergic excitation is suspected to play a role in the genesis of epileptic processes. In the present study we quantified the number of glutamate+ve neurons in the mediodorsal thalamic nucleus (MD) of genetic absence epilepsy rats from Strasbourg (GAERS) and compared these with values for normal Wistar rats.