Comparing glutamatergic neuron population in the mediodorsal thalamic nucleus of genetic absence epilepsy rats from strasbourg (GAERS) and normal control Wistar rats


Cavdar S., Ozgur M., KİRAZLI Ö., Karahuseyinoglu S., Onat F.

JOURNAL OF CHEMICAL NEUROANATOMY, vol.77, pp.93-99, 2016 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jchemneu.2016.05.009
  • Journal Name: JOURNAL OF CHEMICAL NEUROANATOMY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-99
  • Keywords: Glutamate, Mediodorsal thalamic nucleus, Absence epilepsy, Quantification immunohistochemistry, GENERALIZED PENICILLIN EPILEPSY, MAL-LIKE SEIZURES, WAVE DISCHARGES, NONCONVULSIVE EPILEPSY, CORTEX, MODEL, SPIKE, MECHANISMS, SCHIZOPHRENIA, POSTMORTEM
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

An imbalance between GABAergic inhibition and glutamatergic excitation is suspected to play a role in the genesis of epileptic processes. In the present study we quantified the number of glutamate+ve neurons in the mediodorsal thalamic nucleus (MD) of genetic absence epilepsy rats from Strasbourg (GAERS) and compared these with values for normal Wistar rats.