Preparation of amphiphilic glycerol-substituted zinc phthalocyanines using copper-free Sonogashira cross-coupling in aqueous medium


DUMOULIN F. , Ali H., Ahsen V., van Lier J. E.

TETRAHEDRON LETTERS, vol.52, no.34, pp.4395-4397, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 34
  • Publication Date: 2011
  • Doi Number: 10.1016/j.tetlet.2011.06.010
  • Title of Journal : TETRAHEDRON LETTERS
  • Page Numbers: pp.4395-4397

Abstract

Palladium-catalyzed copper-free Sonogashira cross-coupling reactions were performed on a protected and unprotected monoiodotriglycerol substituted Zn(II) phthalocyanine with various alkynes in organic and aqueous medium. From the silyl protected alkyne derivative, a protected homo coupled dimeric product was also prepared using Glaser coupling. All products were purified by reverse phase HPLC and the assigned structures were confirmed by mass and UV-vis spectroscopy. (C) 2011 Elsevier Ltd. All rights reserved.