The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease

BİNGÜL İ., AYDIN A. R., KÜÇÜKGERGİN C., DOĞAN EKİCİ A. I., Dogru-Abbasoglu S., Uysal M.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.3, ss.1500-1511, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2007-289
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1500-1511
  • Anahtar Kelimeler: Vitamin D, fructose, ethanol, oxidative stress, glycation end products, VITAMIN-D PREVENTS, METABOLIC SYNDROME, BETAINE TREATMENT, D DEFICIENCY, RATS, ANTIOXIDANT, FIBROSIS, INJURY, SUPPLEMENTATION, INFLAMMATION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)(2)D-3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)(2)D-3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats.