DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents

Creative Commons License

Citoglu S., Coskun O. D., Tung L. D., Onur M. A., Kim Thanh N. T.

NANOMEDICINE, cilt.16, sa.11, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2217/nnm-2020-0467
  • Dergi Adı: NANOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: cytotoxicity, HeLa, iron oxide cubic nanoparticles, meso-2, 3-dimercaptosuccinic acid (DMSA), SAR, SURFACE MODIFICATION, OLEIC-ACID, MAGNETIC HYPERTHERMIA, IN-VIVO, BIOCOMPATIBILITY, NANOCRYSTALS, EFFICIENCY, SHAPE, SIZE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 +/- 1.9 nm had a specific absorption rate value of 197.4 W/g(Fe) (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 x 10(10), 6.6 x 10(10) and 9.9 x 10(10) NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.