Harmonization initiatives in the generation, reporting and application of biological variation data

Aarsand A. K. , Roraas T., Bartlett W. A. , COŞKUN A. , Carobene A., Fernandez-Calle P., ...Daha Fazla

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.56, sa.10, ss.1629-1636, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 56 Konu: 10
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1515/cclm-2018-0058
  • Sayfa Sayıları: ss.1629-1636


Biological variation (BV) data have many applications in laboratory medicine. However, concern has been raised that some LW estimates in use today may be irrelevant or of unacceptable quality. A number of initiatives have been launched by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and other parties to deliver a more harmonized practice in the generation, reporting and application of BV data. Resulting from a necessary focus upon the veracity of historical BV studies, critical appraisal and meta-analysis of published BV studies is possible through application of the Biological Variation Data Critical Appraisal Checklist (BIVAC), published in 2017. The BIVAC compliant large-scale European Biological Variation Study delivers updated high-quality BV data for a wide range of measurands. Other significant developments include the publication of a Medical Subject Heading term for BV and recommendations for common terminology for reporting of BV data. In the near future, global BV estimates derived from meta-analysis of BIVAC appraised publications will be accessible in a Biological Variation Database at the EFLM website. The availability of these high-quality data, which have many applications that impact on the quality and interpretation of clinical laboratory results, will afford improved patient care.