Biological variation estimates for prostate specific antigen from the European Biological Variation Study; consequences for diagnosis and monitoring of prostate cancer


Carobene A., Guerra E., Locatelli M., Cucchiara V., Briganti A., Aarsand A. K. , ...More

CLINICA CHIMICA ACTA, vol.486, pp.185-191, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 486
  • Publication Date: 2018
  • Doi Number: 10.1016/j.cca.2018.07.043
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.185-191
  • Keywords: Biological variation, Analytical performance specification, Prostate specific antigen, Prostate cancer, REFERENCE CHANGE VALUES, LABORATORY MEDICINE, CLINICAL-CHEMISTRY, QUALITY SPECIFICATIONS, STORAGE-CONDITIONS, SERUM, VARIABILITY, COLLECTION, VOLUNTEERS, FEDERATION

Abstract

Background: Prostate-specific antigen (PSA) is central in the diagnosis of prostate cancer. However, high-quality biological variation (BV) estimates for PSA are scarce. Here BV estimates from the European Biological Variation Study (EuBIVAS) for total (tPSA), free (fPSA), conjugated PSA (cPSA), and percent free PSA (%fPSA) are provided.