Alterations in semen parameters in men with epilepsy treated with valproate

Kose-Ozlece H., Ilik F., Cecen K., Huseyinoglu N., Serim A.

IRANIAN JOURNAL OF NEUROLOGY, vol.14, no.3, pp.164-167, 2015 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2015
  • Journal Name: IRANIAN JOURNAL OF NEUROLOGY
  • Page Numbers: pp.164-167
  • Keywords: Valproate, Male Infertility, Epilepsy, Antiepileptic Drugs, Reproductive Dysfunction
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: Besides the well-known adverse effects of valproate (VPA), disorders related to male reproductive functions have been reported. Furthermore, only a limited number of previous studies have reported the relationship between VPA dose and impairment of the hormonal axis and semen quality. A patient with reversible changes that occurred in the sperm parameters after a dose increment of VPA.