Using intraoperative dynamic contrast-enhanced T1-weighted MRI to identify residual tumor in glioblastoma surgery

ÖZDUMAN K., Yildiz E., Dincer A., Sav A., Pamir M. N.

JOURNAL OF NEUROSURGERY, vol.120, no.1, pp.60-66, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 120 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3171/2013.9.jns121924
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.60-66
  • Keywords: intraoperative magnetic resonance imaging, high-grade glioma, dynamic contrast imaging, glioblastoma, oncology, LOW-GRADE GLIOMA, MALIGNANT GLIOMA, KINETIC-ANALYSIS, BRAIN-TUMORS, BLOOD-VOLUME, RESECTION, GUIDANCE, MULTIFORME, SURVIVAL, EXTENT


Object. The goal of surgery in high-grade gliomas is to maximize the resection of contrast-enhancing tumor without causing additional neurological deficits. Intraoperative MRI improves surgical results. However, when using contrast material intraoperatively, it may be difficult to differentiate between surgically induced enhancement and residual tumor. The purpose of this study was to assess the usefulness of intraoperative dynamic contrast-enhanced T1-weighted MRI to guide this differential diagnosis and test it against tissue histopathology.