Retinal pigment epithelium cell culture on surface modified poly(hydroxybutyrate-co-hydroxyvalerate) thin films

TEZCANER A., Bugra K., Hasirci V. N.

BIOMATERIALS, cilt.24, sa.25, ss.4573-4583, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 25
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0142-9612(03)00302-8
  • Dergi Adı: BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4573-4583
  • Anahtar Kelimeler: retinal pigment epithelium, cell culture, tissue engineering, PHBV, biodegradable, ANTIBIOTIC RELEASE, TISSUE, TRANSPLANTATION, ADHESION, DEGENERATION, POLY(3-HYDROXYBUTYRATE), BIOMATERIALS, FIBRONECTIN, DEGRADATION, ROUGHNESS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

There is currently no effective treatment for the retinal disorders caused by retinal pigment epithelium (RPE) degeneration. Transplantation of allografts is the main strategy towards correction of this malady. Tissue engineering could offer hope and involve the use of biodegradable polymeric templates to replace diseased or lost RPE. In this study PHBV8 film was chosen as a temporary substrate for growing retinal pigment epithelium cells as an organized monolayer before their subretinal transplantation. The surface of the PHBV8 film was rendered hydrophilic by oxygen plasma treatment to increase the reattachment of D407 cells on the film surface.