Orexins cause epileptic activity


Erken H. A. , Erken G., Genc O., Kortunay S., Sahiner M., TURGUT G., ...More

PEPTIDES, vol.37, no.1, pp.161-164, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.peptides.2012.06.012
  • Journal Name: PEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.161-164
  • Keywords: EEG, Epilepsy, Hypocretin, Orexin, Power spectrum, Seizure, DORSAL RAPHE NUCLEUS, SEROTONIN NEURONS, BASAL FOREBRAIN, LOCUS-COERULEUS, OREXIN/HYPOCRETIN, RELEASE, HYPOCRETIN-1, DEPOLARIZES, MODULATION, PEPTIDES
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. (C) 2012 Elsevier Inc. All rights reserved.