Orexins cause epileptic activity

Erken H. A. , Erken G., Genc O., Kortunay S., Sahiner M. , TURGUT G., ...More

PEPTIDES, vol.37, no.1, pp.161-164, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.peptides.2012.06.012
  • Title of Journal : PEPTIDES
  • Page Numbers: pp.161-164


Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. (C) 2012 Elsevier Inc. All rights reserved.