Orexins cause epileptic activity

Erken H. A. , Erken G., Genc O., Kortunay S., Sahiner M. , TURGUT G., ...Daha Fazla

PEPTIDES, cilt.37, ss.161-164, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. (C) 2012 Elsevier Inc. All rights reserved.