Orexins cause epileptic activity

Erken H. A., Erken G., Genc O., Kortunay S., Sahiner M., TURGUT G., ...Daha Fazla

PEPTIDES, cilt.37, sa.1, ss.161-164, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.peptides.2012.06.012
  • Dergi Adı: PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.161-164
  • Anahtar Kelimeler: EEG, Epilepsy, Hypocretin, Orexin, Power spectrum, Seizure, DORSAL RAPHE NUCLEUS, SEROTONIN NEURONS, BASAL FOREBRAIN, LOCUS-COERULEUS, OREXIN/HYPOCRETIN, RELEASE, HYPOCRETIN-1, DEPOLARIZES, MODULATION, PEPTIDES
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. (C) 2012 Elsevier Inc. All rights reserved.