A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia


Ng Ö. , Firtina S., Can I., Karakas Z., Agaoglu L., Dogru O., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.2, pp.127-135, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2013.0296
  • Title of Journal : TURKISH JOURNAL OF HEMATOLOGY
  • Page Numbers: pp.127-135

Abstract

Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.