Patency of ductus arteriosus (PDA) in preterm infants impairs the normal development and convalescence of the infant. Although prostaglandin inhibitors provide a conventional pharmacologic treatment with good results, some patients need surgical PDA closure. Surgical PDA closure in preterm infants necessitates special care due to the high fragility of PDA tissue. Conventional clips or ligation techniques might be traumatic and cause tearing and excessive bleeding which may be difficult to control. In this study, we report an alternative method for PDA closure in preterm infants using Yasargil neurovascular mini-clips, which have been used for years in neurosurgery due to their atraumatic properties.