The role of serum zinc level in febrile convulsion etiology

Kafadar İ., Akıncı A. B., Pekün F., Adal E.

Journal of Pediatric Infection, no.6, pp.90-93, 2012 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Publication Date: 2012
  • Journal Name: Journal of Pediatric Infection
  • Journal Indexes: Other Indexes
  • Page Numbers: pp.90-93
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Objective: Although the mechanism of febrile convulsion is not yet clear, some changes in the level of trace elements such as zinc have been suggested to be responsible for the pathogenesis.

Material and Methods: This study was carried out with 88 children, 40 girls, 48 boys between 672 months of age who visited the Pediatric Emergency Department of Okmeydani Research and Training Hospital from Agust 2009 to November 2009. The children were divided into three groups. The first group included 45 patients with complaints of febrile convulsion, the second group included 23 children who had visited for fever but did not have convulsions, and the third group consisted of 20 healthy children.

Results: Mean serum zinc concentration of patients who had febrile convulsions was 110.49 [+ or -] 35.03 ug/ dL, whereas mean serum zinc concentrations of children with fever and healthy children were 107.12 [+ or -] 21.66 [micro]g/dL and 116.12 [+ or -] 32.07 [micro]g/dL, respectively. There is no statistically significant difference between the three groups in terms of zinc levels. We did not find any difference between serum zinc levels in patients who had one or more convulsions.

Conclusion: Our findings do not support the hypothesis that febrile convulsion is related to reduced serum zinc concentration, thus necessitating further studies involving larger sample sizes in order to understand the role of zinc in the pathogenesis of febrile convulsion.