CLINICAL NEUROLOGY AND NEUROSURGERY, vol.173, pp.20-30, 2018 (SCI-Expanded)
Article / Article
CLINICAL NEUROLOGY AND NEUROSURGERY
Science Citation Index Expanded (SCI-EXPANDED)
Medroxyprogesterone, Progesterone analogues, Dexamethasone, Temozolomide, Glioblastoma, BREAST-CANCER CELLS, PROGESTERONE-RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE, REPRODUCTIVE FACTORS, ENDOMETRIAL CANCER, ADENOVIRUS RECEPTOR, ACETATE MPA, RISK, INVASION, DIFFERENTIATION
Acibadem Mehmet Ali Aydinlar University Affiliated:
Objective: Glial tumor growth may accelerate during gestation, but epidemiological studies consistently demonstrated that parousity reduces life long risk of glial tumors. Pregnancy may also accelerate growth of medulloblastoma and meningioma, but parousity does not confer protection against these tumors. We were the first to show that medroxyprogesterone acetate (MPA) reduces rat C6 glioma growth in vitro. Now we aimed to determine the effects of MPA on human brain cancers (particularly glioblastoma) in vitro and C6 glioma in vivo.