Biological variation data for lipid cardiovascular risk assessment biomarkers. A systematic review applying the biological variation data critical appraisal checklist (BIVAC)

Diaz-Garzon J., Fernandez Calle P., Minchinela J., Aarsand A. K. , Bartlett W. A. , Aslan B., ...More

CLINICA CHIMICA ACTA, vol.495, pp.467-475, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 495
  • Publication Date: 2019
  • Doi Number: 10.1016/j.cca.2019.05.013
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.467-475


Background: Biological variation (BV) data can be used to set analytical performance specifications (APS) for lipid assays. Poor performance will impact upon the efficacy of international guidelines for cardiovascular risk assessment (CVR) and relevant clinical decision limits. This systematic review applies the Biological Variation Data Critical Appraisal Checklist (BIVAC) to published studies of BV of CVR biomarkers enabling metanalysis of the data.