Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

Creative Commons License

Demir I. E., Tieftrunk E., Schorn S., Saricaoglu O. C., Pfitzinger P. L., Teller S., ...More

GUT, vol.65, no.6, pp.1001-1014, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1136/gutjnl-2015-309784
  • Journal Name: GUT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1001-1014
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objective The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal activity and pain sensation.