Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

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Demir I. E., Tieftrunk E., Schorn S., Saricaoglu O. C., Pfitzinger P. L., Teller S., ...Daha Fazla

GUT, cilt.65, sa.6, ss.1001-1014, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1136/gutjnl-2015-309784
  • Dergi Adı: GUT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1001-1014
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal activity and pain sensation.