Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia


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Demir I. E. , Tieftrunk E., Schorn S., Saricaoglu O. C. , Pfitzinger P. L. , Teller S., ...More

GUT, vol.65, no.6, pp.1001-1014, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1136/gutjnl-2015-309784
  • Title of Journal : GUT
  • Page Numbers: pp.1001-1014

Abstract

Objective The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal activity and pain sensation.