Effect of Mitomycin-C on post-operative adhesions in tendon surgery AN EXPERIMENTAL STUDY IN RATS


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Kocaoglu B. , Agir I., Nalbantoglu U., Karahan M., Turkmen M.

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, ss.889-893, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Basım Tarihi: 2010
  • Doi Numarası: 10.1302/0301-620x.92b6.23534
  • Dergi Adı: JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
  • Sayfa Sayıları: ss.889-893

Özet

We investigated the effect of mitomycin-C on the reduction of the formation of peritendinous fibrous adhesions after tendon repair. In 20 Wistar albino rats the tendo Achillis was cut and repaired using a modified Kessler technique. The rats were divided into two equal groups. In group 1, an injection of mitomycin-C was placed between the tendon and skin of the right leg. In group 2, an identical volume of sterile normal saline was injected on the left side in a similar fashion. All the rats received mitomycin-C or saline for four weeks starting from the day of operation. The animals were killed after 30 days. The formation of peritendinous fibrous tissue, the inflammatory reaction and tendon healing were evaluated. The tensile strength of the repaired tendons was measured biomechanically. Microscopic evidence of the formation of adhesions and inflammation was less in group 1. There was no significant difference in the tensile load required to rupture the repaired tendons in the two groups.