In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems

Sendil-Keskin D., Altunay H., Wise D., Hasirci V. N.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, cilt.14, sa.6, ss.497-514, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1163/15685620360674218
  • Dergi Adı: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.497-514
  • Anahtar Kelimeler: PLGA, morphine, codeine, hydromorphone, bupivacaine, controlled release, pain relief, SEVERE CANCER PAIN, TAIL-FLICK TEST, BUPIVACAINE, HYDROMORPHONE, PHARMACOKINETICS, PHARMACODYNAMICS, MICROSPHERES, INFUSION, CODEINE, CONTIN
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Pain is the most common and feared symptom for patients, especially those with cancer. Treatment of chronic pain with conventional ways of medication usually fails with increasing severity of the pain. New approaches enabling the prolonged provision of pain relievers are required. We designed a controlled release system of pain relievers, mainly for opioids (morphine, M, codeine, C, and hydromorphone, HM), and a local anesthetic (bupivacaine, BP) in the form Of poly(L-lactide-colycolide) (PLGA) rods. The efficacy of these rods implanted alone or in combination in relieving chronic pain in rats caused by the ligation of the sciatic nerve of their right hind limbs was studied. The two most common tests for measuring analgesia, i.e. tail-flick tests, that show analgesia at sites other than the site of injury, were used to study the degree of systemic distribution of the drugs and paw-withdrawal tests were used to study the analgesia at the site of injury.