Invasive, Atypical and Aggressive Pituitary Adenomas and Carcinomas


Sav A., Rotondo F., Syro L. V. , Di leva A., Cusimar M. D. , Kovacs K.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, vol.44, no.1, pp.99-105, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.ecl.2014.10.008
  • Title of Journal : ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
  • Page Numbers: pp.99-105

Abstract

Aggressive pituitary adenomas have a high risk of recurrence, a lack of therapeutic response, and resistance to conventional treatment. So far, no satisfactory biomarkers are available for predicting their behavior. Some specific pituitary adenoma histotypes are more prone to follow an aggressive behavior. Pituitary carcinomas are rare and show cerebrospinal and/or systemic metastasis. They have worse prognosis than aggressive adenomas, and radiation is of limited use in their treatment.