Akademik Veri Yönetim Sistemi
XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY, Illinois, Amerika Birleşik Devletleri, 8 - 10 Ağustos 2010, ss.335, (Tam Metin Bildiri)
Kyotorphin (KTP; L-Tyrosine–L-Arginine) is an analgesic dipeptide. It displays opioid type actions, including analgesic effects by releasing opioid pentapeptide metenkephalin from slices of the brain and spinal cord. Unilamellar phospholipid vesicles have attracted a great deal of scientific interest as models for biological membranes. Interaction of Kyotorphin with the membrane of optically trapped DMPC vesicle was investigated by using a Raman Tweezers Spectrometer. DMPC vesicles in different sizes were prepared from powdered phospholipid in a buffer solution. The Raman spectra of trapped vesicles were taken in a diluted buffer solution. The interaction of DMPC vesicles with different KTP concentrations and whether the concentration of KTP increases the degree of the membrane disorder were investigated. Peak intensity ratio of 1086/1065 cm⁻¹, the gauche-to-trans, was used to monitor changes in membrane order. The results are presented in this work.S. M.