Heat shock protein 70 is a useful marker for predicting colorectal cancer

Gunaldi M., Kocoglu H., OKUTURLAR Y., GEDİKBAŞI A., Karabulut M., Alis H., ...Daha Fazla

JOURNAL OF BUON, cilt.20, sa.6, ss.1464-1470, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2015
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1464-1470
  • Anahtar Kelimeler: colon cancer, colorectal cancer, cut-off value, diagnosis, heat shock protein 70, rectal cancer, NATURAL-KILLER-CELLS, SERUM-LEVELS, HSP70, METASTASIS, EXPRESSION, APOPTOSIS, STRESS, BIOMARKER, MEMBRANE, SURVIVAL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose: In colorectal cancer (CRC), as in most of other malignancies, heat shock proteins (HSPs) are overexpressed and are associated with apoptosis, cancer cell proliferation, differentiation, invasion, and metastasis. HSP70 is one of the HSPs and has a promising future in cancer studies for both diagnostic and therapeutic applications. In this study, we tried to evaluate the serum levels of HSP70 in CRC patients, and to evaluate its predictive value of detecting CRC.