Heat shock protein 70 is a useful marker for predicting colorectal cancer


Gunaldi M., Kocoglu H., OKUTURLAR Y. , GEDİKBAŞI A., Karabulut M., Alis H., ...More

JOURNAL OF BUON, vol.20, no.6, pp.1464-1470, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 6
  • Publication Date: 2015
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.1464-1470
  • Keywords: colon cancer, colorectal cancer, cut-off value, diagnosis, heat shock protein 70, rectal cancer, NATURAL-KILLER-CELLS, SERUM-LEVELS, HSP70, METASTASIS, EXPRESSION, APOPTOSIS, STRESS, BIOMARKER, MEMBRANE, SURVIVAL

Abstract

Purpose: In colorectal cancer (CRC), as in most of other malignancies, heat shock proteins (HSPs) are overexpressed and are associated with apoptosis, cancer cell proliferation, differentiation, invasion, and metastasis. HSP70 is one of the HSPs and has a promising future in cancer studies for both diagnostic and therapeutic applications. In this study, we tried to evaluate the serum levels of HSP70 in CRC patients, and to evaluate its predictive value of detecting CRC.