The Assessment of Serum Endocan Levels in Children With Juvenile Idiopathic Arthritis
ARCHIVES OF RHEUMATOLOGY, cilt.33, sa.2, ss.168-173, 2018 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.5606/archrheumatol.2018.6528
- Dergi Adı: ARCHIVES OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.168-173
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Objectives: This study aims to evaluate the levels of serum endocan in children with juvenile idiopathic arthritis (JIA). Patients and methods: Sixty-seven children with JIA (30 males, 37 females; mean age 10.4 +/- 4.9 years; range 2 to 18 years) and a sex- and age-matched healthy control group of 39 children (16 males, 23 females; mean age 9.3 +/- 4.1 years; range 1 to 17 years) were recruited. Patients with JIA were divided into two groups as the clinically active JIA group (n=27) and inactive JIA group (n=40). Results: The median serum endocan level in patients with JIA was significantly higher than in the control group (633.75 ng/L vs. 379.76 ng/L, p<0.01). Comparison between patients with active JIA and inactive JIA was not significant in terms of endocan levels (618.70 ng/L vs. 687.36 ng/L, p=0.34). There was a weak negative correlation between Childhood Health Assessment Questionnaire scores of patients with JIA and serum endocan levels. Conclusion: The high level of serum endocan highlighted the endothelial damage in patients with JIA.