Automated red cell exchange procedures in patients with sickle cell disease

Kozanoglu I., Boga C., Ozdogu H., Sezgin N. , Kizilkilic E., Kural M.

TRANSFUSION AND APHERESIS SCIENCE, vol.36, no.3, pp.305-312, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.transci.2007.03.012
  • Page Numbers: pp.305-312


In automated red cell exchange, about 60% of the patient's red blood cells are exchanged via apheresis for those of the donor. We report the outcome of 83 patients with sickle cell anemia (48 women and 35 men; age range, 17-49 years) who underwent a total of 196 apheresis procedures between December 2003 and October 2006 at our institution. We found that automated red cell exchange involving a reduced citrate infusion rate may provide benefit in the prevention or treatment of Ad vaso-occlusive complications in patients with sickle cell disease and may be associated with protean effects on biochemical dynamics. (c) 2007 Elsevier Ltd. All rights reserved.