In vivo phototoxic effects of a tetraethyleneglycol-substituted Zn phthalocyanine in tumor bearing rats at an enzymatic level

Aykota, Muhammed; Yilmaz, Sevda; Erbis, Halil; Kabay, Nilgun; Kostakoglu, SİNEM; Ahsen, Vefa; DUMOULIN , FABIENNE; Yenisey, Cigdem; Kabay, Burhan

doi:10.1142/s1088424621500024

In vivo phototoxic effects of a tetraethyleneglycol-substituted Zn phthalocyanine in tumor bearing rats at an enzymatic level

Aykota M. R., Yilmaz S., Erbis H., Kabay N., Kostakoglu S., Ahsen V., ...Daha Fazla

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.25, sa.2, ss.120-127, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25 Sayı: 2
Basım Tarihi: 2021
Doi Numarası: 10.1142/s1088424621500024
Dergi Adı: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica
Sayfa Sayıları: ss.120-127
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

A study of the enzymatic changes following the photodynamic treatment on CCL-18-tumor implanted Wistar albino rats. TEG-Pc, a Zn(II) phthalocyanine tetra substituted in non-peripheral position by tetraethylene glycol chains, proved to have good efficiency during in vitro photodynamic experiments. Its in vivo phototoxic effects have been investigated in tumor-bearing Wistar albino rats at an enzymatic level. The evolution of different oxidative markers are reviewed 6 h after the treatment.