Analysis of Mitochondrial DNA Control Region D-Loop in Gliomas: Result of 52 Patients

Yuksel S. K., ÖZDUMAN K., Yilmaz E., PAMİR AKSOY N. A., AKYERLİ BOYLU C.

Turkish Neurosurgery, cilt.31, sa.3, ss.368-372, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5137/1019-5149.jtn.29805-20.2
  • Dergi Adı: Turkish Neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.368-372
  • Anahtar Kelimeler: D-loop, Glioma, Mitochondrial DNA, mtDNA variations, Mutations, CLASSIFICATION, MUTATIONS, TUMORS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

© 2021. All Rights Reserved.AIM: To investigate the effect of mitochondrial DNA (mtDNA) variants mainly in D-loop on glioma biology. MATERIAL and METHODS: Sanger sequencing of D-loop (15971–16451 bp) for 52 glioma patients was performed and the variations were statistically analyzed for gender, WHO classification, morphological grade, IDH/TERT status. RESULTS: Total of 122 variations (51 unique) were identified in 52 patients. C16223T, T16189C, T16311C and T16126C variants were frequently detected. The total variation number was statistically non-significant among the analyzed categories. When individual variants were considered, T16311C and T16224C were statistically significant for WHO classification (p=0.033), morphological grade (p=0.036) and gender (p=0.039), respectively. CONCLUSION: Total variation number in D-loop was not found to be related with clinical variables. Our data suggests that individual variants may play a critical role in glioma biology.