Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats

Yavuz M., Aydın Omay B., Carcak N., Akman O., Raci Yananli H. R., Onat F.

EPILEPSIA, vol.61, pp.2825-2835, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2020
  • Doi Number: 10.1111/epi.16728
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.2825-2835
  • Keywords: absence epilepsy, alpha&#8208, adrenergic receptor 2A, CaMKII, GAERS, stereotypic activity, SWDs, ALPHA(2)-ADRENOCEPTOR ANTAGONIST, SEIZURES, RECEPTOR, CORTEX, MODEL, EEG, NEUROTRANSMISSION, BEHAVIOR, SUBTYPE, ANXIETY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Objective The role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave discharges (SWDs) in genetic absence epilepsy rats from Strasbourg (GAERSs), together with its influence on the behavior and second messenger systems, which may point to the mechanisms to which a possible SWD modulation can be related.