Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats

Yavuz M. , Aydın B., Çarçak N., Akman Ö., Raci Y., Onat F.

EPILEPSIA, vol.61, no.12, pp.2825-2835, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 12
  • Publication Date: 2020
  • Doi Number: 10.1111/epi.16728
  • Title of Journal : EPILEPSIA
  • Page Numbers: pp.2825-2835


Objective The role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave discharges (SWDs) in genetic absence epilepsy rats from Strasbourg (GAERSs), together with its influence on the behavior and second messenger systems, which may point to the mechanisms to which a possible SWD modulation can be related.