Atipamezole, a specific alpha(2A) antagonist, suppresses spike-and-wave discharges and alters Ca2+/calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats

Yavuz M., Aydın Omay B., Carcak N., Akman O., Raci Yananli H. R., Onat F.

EPILEPSIA, vol.61, pp.2825-2835, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2020
  • Doi Number: 10.1111/epi.16728
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.2825-2835
  • Keywords: absence epilepsy, alpha&#8208, adrenergic receptor 2A, CaMKII, GAERS, stereotypic activity, SWDs, ALPHA(2)-ADRENOCEPTOR ANTAGONIST, SEIZURES, RECEPTOR, CORTEX, MODEL, EEG, NEUROTRANSMISSION, BEHAVIOR, SUBTYPE, ANXIETY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objective The role of alpha(2A) adrenergic receptors (alpha(2A)ARs) in absence epilepsy is not well characterized. Therefore, we investigated the outcomes of the specific antagonism of alpha(2A)ARs on the spike-and-wave discharges (SWDs) in genetic absence epilepsy rats from Strasbourg (GAERSs), together with its influence on the behavior and second messenger systems, which may point to the mechanisms to which a possible SWD modulation can be related.