Amplitude integrated electroencephalography (aEEG) is a user friendly technique suitable for long term continuous monitoring of cerebral electrical background activity. It is increasingly being used in monitoring high risk neonates in intensive care units. Newer two-channel aEEG monitors by providing data from both side of the brain may increase the sensitivity for detection of unilateral cerebral injury. Here we report a critically ill preterm neonate with intracranial hemorrhage who was monitored with the two-channel aEEG for 3 weeks continuously. Seizures were clearly detected by monitoring electroencephalographic activity of both hemispheres and efficacy of anticonvulsant therapy was evaluated objectively. Amplitude integrated EEG helps management of critically ill patients as it allows continuous long-term monitoring of brain functions.