The European Biological Variation Study (EuBIVAS): Biological Variation Data for Coagulation Markers Estimated by a Bayesian Model.

Aarsand A. K. , Kristoffersen A. H. , Sandberg S., Støve B., Coşkun A. , Fernandez-Calle P., ...More

Clinical chemistry, vol.67, pp.1259-1270, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2021
  • Doi Number: 10.1093/clinchem/hvab100
  • Title of Journal : Clinical chemistry
  • Page Numbers: pp.1259-1270
  • Keywords: biological variation, within-subject biological variation, analytical performance specification, Bayesian model, reference change value, D-DIMER, DISTRIBUTIONS, PROJECT, PHASE, TIME


BACKGROUND: For biological variation (BV) data to be safely used, data must be reliable and relevant to the population in which they are applied. We used samples from the European Biological Variation Study (EuBIVAS) to determine BV of coagulation markers by a Bayesian model robust to extreme observations and used the derived within-participant BV estimates [CVP(i)] to assess the applicability of the BV estimates in clinical practice.