Hematocrit dependence of the Cole-Cole parameters of human blood


Ulgen Y., SEZDİ M.

2nd International Biomedical Engineering Days Conference, İstanbul, Türkiye, 20 - 22 Mayıs 1998, ss.71-74 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/ibed.1998.710570
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.71-74
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The specific impedance of human erythrocytes suspended in plasma was measured in the frequency range from 100kHz to 1MHz, in samples from nine healthy donors. These samples were diluted with 0.9 % saline in different volumes to obtain samples with different hematocrit values, ranging from 31 to 50, The complex impedance was measured as a function of frequency and then fitted into Cole-Cole diagrams, with rms errors of less than 0.5 %, using a LMS algorithm. Data were interpreted in terms of an equivalent resistor-capacitor circuit. In this hematocrit range, Cole-Cole parameters R-e, R-i, F-c, and alpha, in turn are shown tc, be a linear function of hematocrit (0.98< r <1), As the concentration of red blood cells in blood samples is augmented, the intracellular conductivity is increased while extracellular conductivity is reduced and, Cole-Cole plots are shifted upwards to the right, in the complex plane, indicating a higher alpha and a lower f(c), Cole-Cole parameters might be a potential index for evaluating blood in clinical applications.