Effects of zileuton on the development of autoimmune myocarditis in an experimental rat model


Odemis E. , Turkay S., Koca C., Kiyici H., Karadag A., Bayrak R., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.68, no.4, pp.262-270, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1016/j.curtheres.2007.08.002
  • Title of Journal : CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.262-270

Abstract

Background: Myocarditis is associated with high morbidity and mortality in childhood, but the pathogenesis of this disease is still unclear. Current knowledge indicates that complex immunopathogenic mechanisms are involved. It is understood that leukotrienes play an important role in the inflammation associated with asthma, and recent reports indicate that leukotrienes participate in immune processes and in autoimmunity.