Effects of zileuton on the development of autoimmune myocarditis in an experimental rat model


Odemis E. , Turkay S., Koca C., Kiyici H., Karadag A., Bayrak R., ...Daha Fazla

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.68, ss.262-270, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 68 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.curtheres.2007.08.002
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Sayfa Sayıları: ss.262-270

Özet

Background: Myocarditis is associated with high morbidity and mortality in childhood, but the pathogenesis of this disease is still unclear. Current knowledge indicates that complex immunopathogenic mechanisms are involved. It is understood that leukotrienes play an important role in the inflammation associated with asthma, and recent reports indicate that leukotrienes participate in immune processes and in autoimmunity.