Structural characterization of recombinant bovine Go alpha by spectroscopy and homology modeling

MEGA TİBER P., ORUN O., NACAR C., Sezerman U. O., Severcan F., Severcan M., ...More

SPECTROSCOPY-BIOMEDICAL APPLICATIONS, vol.26, no.4-5, pp.213-229, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4-5
  • Publication Date: 2011
  • Doi Number: 10.1155/2011/808037
  • Journal Name: SPECTROSCOPY-BIOMEDICAL APPLICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.213-229
  • Keywords: Go alpha protein, FTIR spectroscopy, circular dichroism, homology modeling, PROTEIN SECONDARY STRUCTURE, CIRCULAR-DICHROISM, NUCLEOTIDE-BINDING, INFRARED-SPECTRA, FLUORESCENCE, MEMBRANES, SUBUNIT, HADDOCK
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Go, a member of heterotrimeric guanine nucleotide-binding proteins, is the most abundant form of G protein in the central and peripheral nervous systems. Go alpha has a significant role in neuronal development and function but its signal transduction mechanism remains to be clarified.