Gamma knife stereotactic radiosurgery yields good long-term outcomes for low-volume uveal melanomas without intraocular complications

Toktas Z. O., Bicer A., Demirci G., Pazarli H., ABACIOGLU M. U., Peker S., ...Daha Fazla

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.17, sa.4, ss.441-445, 2010 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jocn.2009.08.004
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.441-445
  • Anahtar Kelimeler: Uveal melanoma, Gamma knife radiosurgery, Local tumor control, Stereotactic radiosurgery, Local disease control, PLAQUE RADIOTHERAPY, TRANSPUPILLARY THERMOTHERAPY, CHOROIDAL MELANOMA, BEAM IRRADIATION, TUMOR-CONTROL, ENUCLEATION, EXPERIENCE, MANAGEMENT
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

We present the outcomes of 35 uveal melanoma patients treated with gamma knife stereotactic radiosurgery. All cases were previously untreated. During follow-up, regular MRI examinations were used to detect any changes in tumor size and estimate the local long-term tumor control rate. Treatment-related complications were also recorded. During follow-up, systemic dissemination was observed in two patients, one of whom died of metastases. The most frequent complication was retinal detachment (17.1%). Three patients required enucleation. Cumulative I-year and 3-year local tumor growth control rates were 97% and 83%, respectively. The mean and median times to local tumor progression were 48.0 and 51.7 months, respectively. Gamma knife surgery may be a suitable alternative for the treatment of low-volume uveal tumors without intraocular complications, as the control rate and long-term outcomes compare favorably with those of surgical excision and brachytherapy. (C) 2009 Elsevier Ltd. All rights reserved.