The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel, Aytac; Bildik, Gamze; Senbabaoglu, Filiz; Akin, Nazli; Arvas, Macit; Unal, Fehmi; Kilic, Yagmur; Karanfil, Isil; Eryilmaz, Baldan; Yilmaz, Pelin; Ozkanbas, Can; Taskiran, Cagatay; Aksoy, Senai; Guzel, Yilmaz; Balaban, Basak; Ince, Ümit; Iwase, Akira; Urman, Bulent; Oktem, Ozgur

doi:10.1093/humrep/dev256

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

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Yuksel A., Bildik G., Senbabaoglu F., Akin N., Arvas M., Unal F., ...More

HUMAN REPRODUCTION, vol.30, no.12, pp.2926-2935, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 30 Issue: 12
Publication Date: 2015
Doi Number: 10.1093/humrep/dev256
Journal Name: HUMAN REPRODUCTION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
Page Numbers: pp.2926-2935
Keywords: gemcitabine, cisplatin, cyclophosphamide, ovary, granulosa cells, cytotoxicity, DOSE-RATE INFUSION, GEMCITABINE, PRESERVATION, GROWTH, AGENTS, DAMAGE, MODEL
Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

STUDY QUESTION: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?