The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel, Aytac; Bildik, Gamze; Senbabaoglu, Filiz; Akin, Nazli; Arvas, Macit; Unal, Fehmi; Kilic, Yagmur; Karanfil, Isil; Eryilmaz, Baldan; Yilmaz, Pelin; Ozkanbas, Can; Taskiran, Cagatay; Aksoy, Senai; Guzel, Yilmaz; Balaban, Basak; Ince, Ümit; Iwase, Akira; Urman, Bulent; Oktem, Ozgur

doi:10.1093/humrep/dev256

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel A., Bildik G., Senbabaoglu F., Akin N., Arvas M., Unal F., ...More

HUMAN REPRODUCTION, vol.30, no.12, pp.2926-2935, 2015 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 30 Issue: 12
Publication Date: 2015
Doi Number: 10.1093/humrep/dev256
Title of Journal : HUMAN REPRODUCTION
Page Numbers: pp.2926-2935

Abstract

STUDY QUESTION: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?