The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel, Aytac; Bildik, Gamze; Senbabaoglu, Filiz; Akin, Nazli; Arvas, Macit; Unal, Fehmi; Kilic, Yagmur; Karanfil, Isil; Eryilmaz, Baldan; Yilmaz, Pelin; Ozkanbas, Can; Taskiran, Cagatay; Aksoy, Senai; Guzel, Yilmaz; Balaban, Basak; Ince, ÜMİT; Iwase, Akira; Urman, Bulent; Oktem, Ozgur

doi:10.1093/humrep/dev256

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel A., Bildik G., Senbabaoglu F., Akin N., Arvas M., Unal F., ...Daha Fazla

HUMAN REPRODUCTION, cilt.30, sa.12, ss.2926-2935, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 30 Sayı: 12
Basım Tarihi: 2015
Doi Numarası: 10.1093/humrep/dev256
Dergi Adı: HUMAN REPRODUCTION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2926-2935
Anahtar Kelimeler: gemcitabine, cisplatin, cyclophosphamide, ovary, granulosa cells, cytotoxicity, DOSE-RATE INFUSION, GEMCITABINE, PRESERVATION, GROWTH, AGENTS, DAMAGE, MODEL
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

STUDY QUESTION: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?