The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells


Yuksel A., Bildik G., Senbabaoglu F., Akin N., Arvas M., Unal F., ...More

HUMAN REPRODUCTION, vol.30, no.12, pp.2926-2935, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1093/humrep/dev256
  • Title of Journal : HUMAN REPRODUCTION
  • Page Numbers: pp.2926-2935

Abstract

STUDY QUESTION: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?