The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Yuksel, Aytac; Bildik, Gamze; Senbabaoglu, Filiz; Akin, Nazli; Arvas, Macit; Unal, Fehmi; Kilic, Yagmur; Karanfil, Isil; Eryilmaz, Baldan; Yilmaz, Pelin; Ozkanbas, Can; Taskiran, Cagatay; Aksoy, Senai; Guzel, Yilmaz; Balaban, Basak; Ince, Ümit; Iwase, Akira; Urman, Bulent; Oktem, Ozgur

doi:10.1093/humrep/dev256

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells

Atıf İçin Kopyala

Yuksel A., Bildik G., Senbabaoglu F., Akin N., Arvas M., Unal F., et al.

HUMAN REPRODUCTION, cilt.30, ss.2926-2935, 2015 (SCI İndekslerine Giren Dergi)

Cilt numarası: 30 Konu: 12
Basım Tarihi: 2015
Doi Numarası: 10.1093/humrep/dev256
Dergi Adı: HUMAN REPRODUCTION
Sayfa Sayısı: ss.2926-2935

Özet

STUDY QUESTION: Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro?