Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

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Bergthold G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., ...More

NEURO-ONCOLOGY, vol.17, no.11, pp.1486-1496, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 11
  • Publication Date: 2015
  • Doi Number: 10.1093/neuonc/nov045
  • Journal Name: NEURO-ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1486-1496
  • Keywords: BRAF duplication, BRAF mutation, expression, heterogeneity, pediatric low-grade glioma, GENE-EXPRESSION, PILOCYTIC ASTROCYTOMAS, OPTIC PATHWAY, CANCER, DUPLICATION, RECURRENT, PHOSPHORYLATION, CLASSIFICATION, HETEROGENEITY, ACTIVATION
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that these tumors are mostly driven by mitogene-activated protein kinase (MAPK) pathway alterations. However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity.