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Bergthold G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., ...More
NEURO-ONCOLOGY, vol.17, no.11, pp.1486-1496, 2015 (SCI-Expanded)
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Science Citation Index Expanded (SCI-EXPANDED)
BRAF duplication, BRAF mutation, expression, heterogeneity, pediatric low-grade glioma, GENE-EXPRESSION, PILOCYTIC ASTROCYTOMAS, OPTIC PATHWAY, CANCER, DUPLICATION, RECURRENT, PHOSPHORYLATION, CLASSIFICATION, HETEROGENEITY, ACTIVATION
Acibadem Mehmet Ali Aydinlar University Affiliated:
Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that these tumors are mostly driven by mitogene-activated protein kinase (MAPK) pathway alterations. However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity.