Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

Bergthold, Guillaume; Bandopadhayay, Pratiti; Hoshida, Yujin; Ramkissoon, Shakti; Ramkissoon, Lori; Rich, Benjamin; Maire, Cecile; Paolella, Brenton; Schumacher, Steven; Tabak, Barbara; Ferrer-Luna, Ruben; Ozek, MEMET; Sav, Aydin; Santagata, Sandro; Wen, Patrick; Goumnerova, Liliana; Ligon, Azra; Stiles, Charles; Segal, Rosalind; Golub, Todd; Grill, Jacques; Ligon, Keith; Chan, Jennifer; Kieran, Mark; Beroukhim, Rameen

doi:10.1093/neuonc/nov045

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype

Bergthold G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., ...Daha Fazla

NEURO-ONCOLOGY, cilt.17, sa.11, ss.1486-1496, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 11
Basım Tarihi: 2015
Doi Numarası: 10.1093/neuonc/nov045
Dergi Adı: NEURO-ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1486-1496
Anahtar Kelimeler: BRAF duplication, BRAF mutation, expression, heterogeneity, pediatric low-grade glioma, GENE-EXPRESSION, PILOCYTIC ASTROCYTOMAS, OPTIC PATHWAY, CANCER, DUPLICATION, RECURRENT, PHOSPHORYLATION, CLASSIFICATION, HETEROGENEITY, ACTIVATION
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that these tumors are mostly driven by mitogene-activated protein kinase (MAPK) pathway alterations. However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity.