Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia

Cakir, Tunahan; Alsan, Selma; Saybasili, Hale; Akin, ATA; Ulgen, Kutlu

doi:10.1186/1742-4682-4-48

Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia

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Cakir T., Alsan S., Saybasili H., Akin A., Ulgen K. O.

THEORETICAL BIOLOGY AND MEDICAL MODELLING, vol.4, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 4
Publication Date: 2007
Doi Number: 10.1186/1742-4682-4-48
Journal Name: THEORETICAL BIOLOGY AND MEDICAL MODELLING
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: It is a daunting task to identify all the metabolic pathways of brain energy metabolism and develop a dynamic simulation environment that will cover a time scale ranging from seconds to hours. To simplify this task and make it more practicable, we undertook stoichiometric modeling of brain energy metabolism with the major aim of including the main interacting pathways in and between astrocytes and neurons.