Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia


Cakir T., Alsan S., Saybasili H., Akin A. , Ulgen K. O.

THEORETICAL BIOLOGY AND MEDICAL MODELLING, vol.4, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2007
  • Doi Number: 10.1186/1742-4682-4-48
  • Title of Journal : THEORETICAL BIOLOGY AND MEDICAL MODELLING

Abstract

Background: It is a daunting task to identify all the metabolic pathways of brain energy metabolism and develop a dynamic simulation environment that will cover a time scale ranging from seconds to hours. To simplify this task and make it more practicable, we undertook stoichiometric modeling of brain energy metabolism with the major aim of including the main interacting pathways in and between astrocytes and neurons.