The effect of ketamine administered preoperatively through different routes on thoracotomy pain: A randomized, double blind, placebo controlled study Torakotomi aǧrisinda preoperatif farkli yollardan uygulanan ketaminin etkinliǧi: Randomize, çift kör, plasebo kontrollü klinik çalişma
Agri, cilt.14, sa.2, ss.54-59, 2002 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2002
- Dergi Adı: Agri
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.54-59
- Anahtar Kelimeler: Ketamine, Postoperative pain, Preemptive analgesia, Thoracotomy
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
We have evaluated the efficacy of application of ketamine via intramuscular and epidural routes in postthoracotomy pain. The study was designed as randomised, double blinded, plasebo-controlled. With the approval of the Faculty Ethics Committee 30 patients going under elective thoracotomy due to various reasons were included in the study. The patients were devided into 3 equal groups. Group IM had i.m. ketamine (1 mg/kg) in 2 ml + epidural normal. saline, Group EPI had epidural ketamine (0.5 mg/kg) in 10ml + i.m. normal saline, Group K had epidural 10 normal saline + im. 2ml normal saline. All patients had standard anesthetic technique. Postoperative analgesia was maintained with epidural patient controlled analgesia using local anesthetic (bupivacaine:1.25 mg/ml) and opioid (morphine: 0.075 mg/ml) combination with the parameters; loading dose: 5ml, bolus dose: 5 ml, lock-out interval: 30min, 4-hours limit: 20ml. The patients were ordered to use the PCA when their VAS scores were 4 and higher. VAS values and the analgesic consumptions were evaluated at 2, 4, 6, 12, 24 and 48 hours, postoperatively. No significant differences between the groups with respect to demographic features (age, gender) were detected. The intraoperative and postoperative opioid consumptions and local anesthetic consumptions were similar between the groups. Group EPI had significantly lower VAS values when compared to the other groups Lit early postoperative period. We have concluded that preoperative epidural application of ketamine reduces postoperative pain.