COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma

Erkanli S., Bolat F., Kayaselcuk F., Demirhan B., Kuscu E.

GYNECOLOGIC ONCOLOGY, vol.104, no.2, pp.320-325, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ygyno.2006.08.044
  • Journal Name: GYNECOLOGIC ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.320-325
  • Keywords: COX-2, survivin, endometrial carcinoma, CYCLOOXYGENASE-2 EXPRESSION, MESSENGER-RNA, TISSUE MICROARRAY, EPITHELIAL-CELLS, GROWTH-FACTOR, CANCER, APOPTOSIS, PROTEIN, PTEN, RECEPTORS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objectives. To investigate the expressions of survivin and Cyclooxygenase-2 (COX-2), and their possible correlations in the development of endometrial adenocarcinoma (EC). We also looked at their association with classical prognostic factors in EC. To our knowledge, this is the first time survivin expression is investigated in terms Of its relation to COX-2 in the developmental pathway of EC.