Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

Tayyar A. T. , Tayyar A., Kozali S., Karakus R., Eser A., Yayla C. A. , ...More

HYPERTENSION IN PREGNANCY, vol.38, no.1, pp.13-19, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1080/10641955.2018.1540702
  • Page Numbers: pp.13-19


Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = -.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.